The General Assembly of the Presbyterian Church (U.S.A.) meets biennially in even-numbered years. It consists of commissioners elected by each of its 172 presbyteries. The GA is full of activities: business sessions, committee meetings, an exhibit hall, daily worship services, and mission tours sponsored by the  Committee on Local Arrangements.

The assembly acts on hundreds of items of business, which it receives through the reports and recommendations of various assembly entities, and through overtures from synods and presbyteries.

The 222nd General Assembly (2016) will be held in Portland, Oregon—June 18–25, 2016.